MONROVIA – The National Public Health Institute of Liberia (NPHIL), through the Case Management Pillar led by the Ministry of Health, has confirmed four deaths associated with Mpox and other underlying health conditions at treatment facilities in Monrovia and Buchanan.
According to NPHIL, three of the fatalities occurred at the Starbase Isolation Facility in Monrovia, while one was recorded at the Liberian Government Hospital in Buchanan, Grand Bassa County. Investigations are ongoing under the Mpox National Incident Management System (IMS).
Hospital reports indicate that some of the deceased patients had co-infections or underlying conditions, including HIV/AIDS and sepsis, which may have contributed to their deaths.
These are the first Mpox-related fatalities reported in Liberia since the Africa Centers for Disease Control and Prevention (Africa-CDC) and the World Health Organization (WHO) declared the outbreak in August 2024. To support the investigation, the National Reference Laboratory at NPHIL will conduct genomic sequencing of samples from the deceased.
NPHIL noted that Liberia’s public health surveillance and response system remains on heightened alert amid an upsurge of Mpox cases in the West African sub-region. The Institute is strengthening cross-border surveillance, intensifying active case searches, and enhancing diagnostic capacity to break human-to-human transmission. Hospitals and isolation centers are also being urged to improve case management to reduce fatalities.
Mpox, caused by the monkeypox virus, is generally self-limiting but can be severe in some cases.
As of September 29, 2025, Liberia has recorded 923 laboratory-confirmed cases, with 169 active cases, 750 recoveries, and four fatalities.
NPHIL is advising the public to remain calm, avoid panic, and adhere strictly to preventive measures, including frequent handwashing, avoiding contact with suspected cases, and reporting symptoms to the nearest health facility or by calling the emergency number 4455.
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